Andrea Masotti, PhD
 
Gene Expression - Microarrays Laboratory
Bambino Gesù Children's Hospital, IRCCS
Piazza S. Onofrio 4, 00165 Rome
Tel: +39 0668592650; Mobile: +39 3345093862; +39 3470181867
Fax: +39 06233234321; +39 0668592904
Skype: andrea_masotti


Activities

  • Gene expression and post-transcriptional regulation by microRNAs (experimental and computational activities) in pediatric diseases.
  • Non-coding RNAs (RNA-Seq and Small RNA-Seq) in eukaryotes and prokaryotes. 
  • Circulating microRNAs for diagnostic and therapeutic applications. 
  • Exome sequencing of rare pediatric diseases and bioinformatics analysis.
  • Nanotechnology and polymer science applied to the in vitro and in vivo delivery of nucleic acids.
  • Surace C, Berardinelli F, Masotti A, Roberti MC, Da Sacco L, D'Elia G, Sirleto P, Digilio MC, Cusmai R, Grotta S, Petrocchi S, Hachem ME, Pisaneschi E, Ciocca L, Russo S, Lepri FR, Sgura A, Angioni A. Telomere shortening and telomere position effect in mild ring 17 syndrome. Epigenetics Chromatin. 2014 Jan 7;7(1):1. doi: 10.1186/1756-8935-7-1.
  • Masotti A, Caporali A. Preparation of Magnetic Carbon Nanotubes (Mag-CNTs) for Biomedical and Biotechnological Applications. Int. J. Mol Sci. 2013 Dec 18;14(12):24619-42. doi: 10.3390/ ijms141224619.
  • Masotti A, Laurenzi C, Boenzi S, Pastore A, Taranta A, Bellomo F, Muraca M, Dionisi-Vici C, Bertucci P, Strologo LD, Emma F. Gender-related effects on urine L-cystine metastability. Amino Acids. 2013 Dec 11. [Epub ahead of print]
  • Letizia Da Sacco, Antonella Baldassarre and Andrea Masotti, Diet’s role in the toxicity of inorganic arsenic (iAs): a journey from soil to children's mouth, J. Geochem. Explor, 2013, 131, 45–51.
  • Paolo Uva, Letizia Da Sacco, Manuela Del Cornò, Antonella Baldassarre, Paola Sestili, Massimiliano Orsini, Alessia Palma, Sandra Gessani and Andrea Masotti, Rat mir-155 generated from the lncRNA Bic is ‘hidden’ in the alternate genomic assembly and reveals the existence of novel mammalian miRNAs and clusters, RNA, 2013 19(3):365-79.
  • A. Masotti, Niosomes as candidate bioconjugates for imaging and pH-sensitive drug delivery nanocarriers for rare pediatric tumors, J. Drug Del. Sci. Tech., 23 (1) 22-24 2013.
  • Da Sacco L, Masotti A. Recent Insights and Novel Bioinformatics Tools to Understand the Role of MicroRNAs Binding to 5' Untranslated Region. Int J Mol Sci. 2012;14(1):480-95.
  • Baldassarre A, Masotti A. Long Non-Coding RNAs and p53 Regulation. Int J Mol Sci. 2012;13(12):16708-17.
  • Andrea Masotti, Comment on: Visinoni et al. The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity. Diabetes 2012;61:1122-32 (in press)
  • Andrea Masotti, Interplays between gut microbiota and gene expression regulation by miRNAs, Frontiers in Cellular and Infection Microbiology, Research topic: Human gut microbiota: onset and shaping through life stages and perturbations, 2012, (submitted)
  • L. Da Sacco and A.Masotti, Children don't like arsenic in their food. J Expo Sci Environ Epidemiol. 2012 Jul;22(4):424-5.
  • Del Chierico F, Masotti A, Onori M, Fiscarelli E, Mancinelli L, Ricciotti G, Alghisi F, Dimiziani L, Manetti C, Urbani A, Muraca M, Putignani L., MALDI-TOF MS proteomic phenotyping of filamentous and other fungi from clinical origin, J Proteomics. 2012 Jun 18;75(11):3314-30.
  • A. Taranta, C. Bizzarri, A. Masotti, G. Sciré, V. Pampanini and Marco Cappa, A case of primary selective hypoaldosteronism carrying three mutations in the aldosterone synthase (Cyp11b2) gene, Gene. 2012 May 25;500(1):22-7.
  • R. De Vito, A.Alisi, A.Masotti, S.Ceccarelli, N.Panera, A.Citti, M.Salata, L.Valenti, A.E.Feldstein and V.Nobili. Markers of activated inflammatory cells correlate with severity of liver damage in children with nonalcoholic fatty liver disease, Int J Mol Med. 2012 Jul;30(1):49-56.
  • Da Sacco L, Baldassarre A and Masotti A, Bioinformatics Tools and Novel Challenges in Long Non-Coding RNAs (lncRNAs) Functional Analysis, Int J Mol Sci. 2012; 13(1): 97-114.
  • Masotti A, Alisi A., Integrated bioinformatics analysis of microRNA expression profiles for an in-depth understanding of pathogenic mechanisms in non-alcoholic fatty liver disease. J Gastroenterol Hepatol. 2012 Feb;27(2):187-8.
  • Masotti A. Mendelian Disorders of Membrane Trafficking, N Engl J Med, (2011),365(21), 2038-2039.
  • Masotti A. Multifunctional Nanoparticles, Nanocages and Degradable Polymers as a Potential Novel Generation of Non-Invasive Molecular and Cellular Imaging Systems. Recent Pat Nanotechnol. (2011); 5:163-177.
  • Alisi A, Da Sacco L, Bruscalupi G, Piemonte F, Panera N, De Vito R, Leoni S, Bottazzo GF, Nobili V and Masotti A. Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease. Lab Invest. (2011), Feb;91(2):283-93.
  • Zanni G, Barresi S, Travaglini L, Bernardini L, Rizza T, Digilio MC, Mercuri E, Cianfarani S, Valeriani M, Ferraris A, Da Sacco L, Novelli A, Valente EM, Dallapiccola B, Bertini ES. FGF17, a gene involved in cerebellar development, is downregulated in a patient with Dandy-Walker malformation carrying a de novo 8p deletion. Neurogenetics. 2011 Aug;12(3):241-5.
  • A. Masotti, L. Da Sacco, GF Bottazzo and A. Alisi. Microarray Technology: a Promising Tool in the Field of Nutrigenomics Discoveries, Crit Rev Food Sci Nutr. (2010); 50(7):693-8.
  • L. Da Sacco and A. Masotti, Chitin and Chitosan as Multipurpose Natural Polymers for Groundwater Arsenic Removal and As2O3 Delivery in Tumor Therapy, Mar. Drugs (2010), 8(5):1518-1525.
  • A. Masotti, P. Vicennati, A. Alisi, C. Marianecci, F. Rinaldi, M. Carafa, G. Ortaggi, Novel Tween®20 derivatives enable the formation of efficient pH-sensitive drug delivery vehicles for human hepatoblastoma, Bioorg Med Chem Lett, (2010); 20(10), 3021-5.
  • N. Panera, A. Alisi, A. Masotti, L. Da Sacco, M. Pezzullo, R. Devito, G. Bruscalupi, S. Leoni, M. Manco, V. Nobili, Inflammatory molecules involved in non-alcoholic steatohepatitis in rats fed different diets, Dig Liver Dis, (2010), 42(S1), S47-S48.
  • Masotti A., Multifuntional nanoparticles: preparation and applications in biomedicine and in non-invasive bioimaging. Recent Pat Nanotechnol. 2010 Jan;4(1):53-62.
  • Del Cornò M, Michienzi A, Masotti A, Da Sacco L, Bottazzo GF, Belardelli F, Gessani S. CC chemokine ligand 2 down-modulation by selected Toll-like receptor agonist combinations contributes to T helper 1 polarization in human dendritic cells. Blood. 2009 Jul 23;114(4):796-806.
  • Barbato C, Arisi I, Frizzo ME, Brandi R, Da Sacco L, Masotti A. Computational challenges in miRNA target predictions: to be or not to be a true target? J Biomed Biotechnol. 2009;2009:803069.
  • A. Alisi, A. Masotti, L. Da Sacco, F. Piemonte, R. Devito, A. Alterio, G. Bruscalupi, S. Leoni, G.F. Bottazzo, V. Nobili, MicroRNA expression profiles in liver tissues from rat fed high fat/high carbohydrate diet may help to elucidate molecular pathogenesis of non-alcoholic fatty liver disease. Journal of Hepatology, 2009, 50, S254-S255.
  • Anna Alisi, Andrea Masotti and Valerio Nobili. Profiling MicroRNA Expression: a Snapshot of Nonalcoholic Steatohepatitis and a Recording of its Pathogenesis, Hepatology. 2009 Feb;49(2):706-7.
  • Masotti A, Caputo V, Da Sacco L, Pizzuti A, Dallapiccola B, Bottazzo GF. Quantification of small non-coding RNAs allows an accurate comparison of miRNA expression profiles. J Biomed Biotechnol. 2009;2009:659028.
  • E. Sturchio, C. Minoia, M. Zanellato, A. Masotti, E. Leoni, C. Sottani, G. Biamonti, A. Ronchi, L. Casorri, S. Signorini, M. Imbriani. Endocrine disruptors -- Monograph. 3. Arsenic. G Ital Med Lav Ergon. 2009 Jan-Mar;31(1):5-32.
  • Masotti A, Da Sacco L, Bottazzo GF, Sturchio E. Risk assessment of inorganic arsenic pollution on human health. Environ Pollut. 2009 Jun;157(6):1771-2.
  • Masotti A, Ortaggi G. Chitosan micro- and nanospheres: fabrication and applications for drug and DNA delivery. Mini Rev Med Chem. 2009 Apr;9(4):463-9.
  • Pampaloni F, Stelzer EH, Masotti A. Three-dimensional tissue models for drug discovery and toxicology. Recent Pat Biotechnol. 2009;3(2):103-17.
  • A. Masotti, G. Mossa, C. Cametti, G. Ortaggi, A. Bianco, N. Del Grosso, D. Malizia, C. Esposito, Comparison of different commercially available cationic liposome-DNA lipoplexes: parameters influencing toxicity and transfection efficiency, Colloids and Surfaces B: Biointerfaces, (2009), 68(2):136-44.