NORWAY


Prof. Philippe Collas
University of Oslo
Institute of Basic Medical Sciences
Department of Molecular Medicine
PO Box 1112
Blindern, 0317 Oslo (Norway)


Team

Dr. Nolwenn Briand (Project Leader)
Dr. Julia Madsen Østerbye (Postdoc)
Evdokiia Potolitsyna (PhD student)
Louise Petersen (PhD student)
Anita Sørensen (Senior engineer)
Sarah Pickering (Bioinformatics engineer)
Mohamed Abdelhalim (Bioinformatics engineer)


Topics of interest

Nuclear architecture
Epigenetics
Gene regulation
Lipodystrophic laminopathies
Nuclear lamins
Adipose stem cell differentiation
Adipocyte biology and physiology


Publications

  • Brunet A, Forsberg F, Fan Q, Sæther T, Collas P. 2019. Nuclear lamin B interactions with chromatin during the circadian cycle are uncoupled from periodic gene expression. Front Genet, doi: 10.3389/fgene.2019.00917
  • Paulsen J, Liyakat Ali TML, Nekrasov M, Delbarre E, Baudement, MO, Kurscheid S, Tremethick D, Collas P. 2019. Long-range interactions between topologically-associating domains shape the 4-dimensional genome during differentiation. Nature Genet 51, 835-843
  • Briand N, Guénantin AC, Jeziorowska D, Shah A, Mantecon M, Capel E, Garcia M, Oldenburg A, Paulsen J, Hulot JS, Vigouroux C, Collas P. 2018. The lypodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks. Hum Mol Genet 27, 1447-1459
  • Oldenburg AR, Briand N, Sørensen AL, Cahyani I, Shah A, Moskaug JØ, Collas P. 2017. A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus. J Cell Biol. 216, 2731-2743
  • Guénantin AC, Briand N, Capel E, Dumont F, Morichon R, Provost C, Stillitano F, Jeziorowska D, Siffroi JP, Hajjar RJ, Fève B, Hulot JS, Collas P, Capeau J, Vigouroux C. 2017. Functional human beige adipocytes from induced pluripotent stem cells. Diabetes 66, 1470-1478
  • Paulsen J, Sekelja M, Oldenburg AR, Barateau A, Briand N, Delbarre E, Shah, A, Sørensen AL, Vigouroux C, Buendia B, Collas P. 2017. Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts. Genome Biol. 18, 21-29
  • Lund EG, Duband-Goulet I, Oldenburg A, Buendia B, Collas P. 2015. Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or microccal nuclease-digested chromatin. Nucleus 6, 30-39
  • Shah, A., Oldenburg, A.R., Collas, P. 2014. A hyper-dynamic nature of bivalent promoter states underlies coordinated developmental gene expression modules. BMC Genomics 15, 1186
  • Lund E., Oldenburg A.R., Delbarre E., Freberg C.T., Duband-Goulet I., Eskeland R., Buendia B., Collas P. 2013. Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes. Genome Res. 23, 1580-1589