Stem Cell Laboratory
BioCruces Research Institute / Hospital Universitario Cruces
Plaza de Cruces s/n. 48903 Barakaldo (Bizkaia)
Phone: +34 946006376 (ext. 2434)

Team

Arantza Infante Martinez, PhD (Postdoctoral Investigator)
Garbiñe Ruiz de Eguino Gabiña (PhD Student)
Andrea Gago Martinez, MD (PhD Student)

Activities

Basic Research: Laminopathies, LMNA-linked lipodystrophies, generation of human diseases models, human mesenchymal stem cells, Induced pluripotent stem cells (iPSCs), Aging

Equipment and facilities

All the information regarding the Center is available at: http://www.biocruces.com

Publications

• Infante A, Ruiz de Eguino, Gago A and Rodríguez C.I. Adipogenesis: Signaling Pathways, Molecular Regulation and Impact on Human Disease. LMNA-linked lipodystrophies: experimental models to unravel the molecular mechanisms. Review by invitation. Nova Science Publishers. In Press.
• Ruiz de Eguino G, Infante A., Schlangen K, Aransay A, Fullaondo A, Soriano M, García-Verdugo JM, Martín AG and Rodríguez C.I. Sp1 transcription factor interaction with accumulated prelamin A impairs adipose lineage differentiation in human mesenchymal stem cells: essential role of Sp1 in the integrity of lipid vesicles. Stem Cells Translational Medicine. 1 (4):309-321. 2012.
  
• Trinidad J., Arruebarrena G., Sáenz de Argandoña E., Ruiz de Eguino G., Infante A., Rodríguez C.I. Evaluation of magnesium alloys with alternative surface finishing for the proliferation and chondro-differentiation of human mesenchymal stem cells. Journal of Physics- Conference Series. 252 012010. 2010.
• Rodríguez C.I., Stewart C.L.; Cell Therapy. Chapter 30: Therapeutic Strategies Using Genetically Modified cells. Lilly Foundation. Editorial McGraw-Hill. 2008.
• Rodríguez C.I., Stewart C.L; Disruption of the ubiquitin ligase HERC4 causes defects in spermatozoon maturation and impaired fertility. Developmental Biology. Dec 15; 312 (2): 501-8, 2007.
• Rodríguez C.I., Simón C.; Human Embryonic Stem Cell Derivation: From the IVF perspective to therapeutic applications. Regenerative Med. 1(1); 103-109, 2006.
• Rodríguez C.I., Galan A., Valbuena D., Simon C.; Derivation of clinical-grade human embryonic stem cells. Reprod Biomed Online. Jan; 12(1): 112-118, 2006.
• Makishima T, Rodríguez C.I., Robertson N.G., Morton C.M., Stewart C.L., Griffith A.J; Targeted disruption of mouse Coch provides functional evidence that DFNA9 hearing loss is not a COCH haploinsufficiency disorder. Human Genetics. 118(1): 29-34, 2005.
• Rodríguez C.I., Cheng JrG, Liu L., Stewart C. L.; Cochlin, a secreted VWA domain containing factor, is regulated by LIF in the uterus at the time of embryo implantation. Endocrinology. Mar; 145(3):1410-8, 2004.
• Rodríguez C.I., Girones N., Fresno M.; Cha, a basic helix-loop-helix transcription factor involved in the regulation of upstream stimulatory factor activity. J. Biol Chem., Oct 31; 278(44):43135-45, 2003.